Show Notes
Part 2 of 4 of our series with Nicole Paulk, founder, CEO, and president of SIREN Biotechnology.
In this episode of The Biotech Startups Podcast, we continue founder, CEO, and president of Siren Biotechnology, Nicole Paulk's journey from small-town farm kid to pioneering gene therapy scientist. Nicole recounts how a Craigslist ad landed her in the lab of one of the most celebrated stem cell scientists in the country, Markus Grompe — blissfully unaware of his fame, she spent months calling him "Marky Mark," planting whoopee cushions under his chair, and filling donut holes with Sriracha, only to discover he was the stem cell adviser to the President of the United States. She reflects on her PhD years as the "golden, pure, best days" of her scientific life, then contrasts that with the culture shock of Stanford's relentless postdoc hustle, a world of constant CV-optimization and pressure to pursue academia at all costs. Nicole shares how landing a coveted K01 grant gave her the credentials to walk through any university door she wanted, eventually bringing her to UCSF just nine months before COVID would turn everything upside down.
Key topics covered:
- The Craigslist Lab Discovery: How one unscripted career move led Nicole to one of the most celebrated stem cell labs in the country
- Working With Markus Grompe: Pranks, camaraderie, and world-class science in a lab that had culture before culture was a thing
- PhD vs. Postdoc: Free-spirited curiosity versus the relentless CV-optimization grind of Stanford
- Academic Pressure & Identity: Why postdoc culture pushes trainees toward academia at all costs — and why that needs to change
- From Stanford to UCSF: A K01 grant, a bold leap to UCSF, and then COVID hits
Resources & Articles
- AAV (Adeno-Associated Virus) Gene Therapy: https://en.wikipedia.org/wiki/Adeno-associated_virus
- Stem Cell Research in the 2000s: https://www.ebsco.com/research-starters/history/stem-cell-research-2000s
- The Oregon Stem Cell Center at OHSU: https://www.ohsu.edu/stem-cell-center
- NIH K01 Mentored Research Scientist Development Award: https://grants.nih.gov/grants/guide/pa-files/PA-24-176.html
- PhD vs. Postdoc: Mental Health & Pressure in Academia: https://pmc.ncbi.nlm.nih.gov/articles/PMC11693439/
- COVID-19's Impact on Academic Research Labs: https://www.nature.com/articles/d41586-021-00663-2
Organizations & People
- OHSU (Oregon Health & Science University): https://www.ohsu.edu
- Stanford University: https://www.stanford.edu
- UCSF (University of California, San Francisco): https://www.ucsf.edu
- Markus Grompe: https://www.linkedin.com/in/markus-grompe-m-d-66211273/
- Mark A. Kay: https://www.linkedin.com/in/mark-kay-md-phd-41a7313/




