Caleb Appleton is a Partner at Bison Ventures, an early-stage venture capital firm investing in frontier technology across robotics, AI, and biology.
At Bison Ventures, Caleb focuses on investments at the intersection of biology and computation—backing companies developing novel therapeutics platforms, data-driven discovery tools, and enabling technologies that reshape how science gets done. He invests from pre-seed through Series B with an average check size of $5 million.
Before joining Bison Ventures, Caleb served as Principal at Innovation Endeavors, where he focused on frontier technology investments across synthetic biology and AI-driven drug discovery. His first investment—a surgical robotics company—became his pathway to partnership, and a cold email to a Berkeley professor led to an investment in Icon Therapeutics, now valued in the multiple billions.
Caleb also brings operating experience from Tune In, where he led a turnaround managing $50 million in revenue during the pandemic, and earlier consulting experience at Bain advising Fortune 500 companies.
.png)